Cisplatin and aki and autophagy
WebFeb 2, 2024 · Some scholars have found that in the cisplatin-induced AKI mice, the C. cicadae mycelium extract regulated the inflammatory response by inhibiting renal pathological changes, inflammatory cell infiltration, and the release of a variety of inflammatory cytokines such as TNF-α, IL-1β, and IL-6. WebNov 3, 2024 · The kidney injury caused by cisplatin can present in a variety of ways. As it was clearly proved in some researches, the most serious and common damage induced by cisplatin is acute kidney injury (AKI) …
Cisplatin and aki and autophagy
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WebAug 5, 2024 · As described in this overview, autophagy is deeply involved in the cisplatin-induced AKI, and autophagy could be a target for kidney protection ( Figure 2 ). Figure … WebCisplatin, a chemotherapeutic agent, is a known nephrotoxin and can cause AKI. The cisplatin treatment induces a time-dependent increase in the LC3 expression in proximal tubular epithelial cells. 23 The inhibition of autophagy through either treatment with 3-MA or knockdown of Becn1 by short-hairpin RNA or siRNA, or Atg5 by siRNA resulted in ...
WebIn AKI mice induced by injection of a single dose of cisplatin (15 mg/kg), oral administration of kaempferide (50 mg/kg) either before or after cisplatin injection markedly improved renal function, and ameliorated renal tissue damage. WebThe apoptosis induced by cisplatin in mice increased evidently compared with the control group, which was decreased in the mice with neferine pretreatment. What' more, we found that autophagy increased obviously in mice pretreated by neferine contrast to …
WebThe delivery of an approved agent such as rapamycin in a PFC NP format enhances local delivery and offers a novel mechanism-based prophylactic therapy for cisplatin-induced acute kidney injury. For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10–20% of all cancer patients. … WebApr 25, 2014 · The role of autophagy in cisplatin-induced AKI is discussed in the next section. 4.2. Autophagy Autophagy is a cellular process of “self-eating” in which …
Web1 day ago · In this study, a natural product from Osage Orange, pomiferin, was identified as a novel autophagy activator that circumvents innate resistance by triggering autophagic cell death via SERCA inhibition and activation of the CaMKKβ-AMPK-mTOR signaling cascade. In addition, pomiferin also directly inhibited the P-gp (MDR1/ABCB1) efflux and ...
WebApr 27, 2024 · Aims:Cisplatin, an anticancer drug, always leads to nephrotoxicity by causing mitochondrial dysfunction. As a major mechanism for cellular self-degradation, autophagy has been proven to protect against cisplatin … detox slimming smoothiesWebDec 12, 2024 · Cisplatin can induce AKI through ischemic damage, by reducing the blood flow in the medulla of the kidneys leading to tubular cell injury. Vasoconstriction due to … church bake sale near meWebAutophagy is induced in proximal tubules during cisplatin nephrotoxicity in C57BL/6 mice C57BL/6 mice (male, 8–10 weeks old) were injected with 25mg/kg cisplatin or saline as control. (A) After the indicated time, kidneys were harvested to collect cortical and outer medulla tissues for immunoblot analysis of LC3 and β-actin (loading control). church balance sheet excelWebDec 7, 2024 · Genetic ablation of the renal tubular (RT) Atg7 gene or pharmacological inhibition of autophagy suppressed the protective effects of HDAC6. Taken together, our study indicates that HDAC6 contributes to ischemia- and cisplatin-induced AKI by inhibiting autophagy and the acetylation of α-tubulin. detox smoothie hcgWebNov 26, 2024 · The inhibition of cisplatin-induced autophagy increases cisplatin-induced apoptosis, suggesting the synergistic induction on cancer cell death via inhibiting cisplatin-induced autophagy activity [39,43]. Thus, through the inhibition of chemotherapy-induced autophagy, ginkgolic acids can enhance the sensitivity of cancer cells to chemotherapy. detox-smoothie aus dem thermomixWebAcute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic cell death characterized by membrane lipid peroxide … church bake sales near meWebNov 1, 2024 · Cisplatin treatment was associated with the activation of autophagy and mitophagy. Rapamycin, a pharmacological inhibitor of mTOR, stimulated autophagy and mitophagy, and alleviated the... church balance sheet sample