Web23 de dez. de 2024 · Thus, high-fidelity Cas13 variants with minimal collateral effect are now available for targeted degradation of RNAs in basic research and therapeutic … Webdevelopment of high-fidelity Cas13 variants with markedly reduced collateral effects by mutagenesis and demonstrated the feasibility of hfCas13 for efficient on-target RNA degradation with almost no

Researchers design high-fidelity Cas13 varian EurekAlert!

Web18 de fev. de 2024 · Yang et al. demonstrated that RNA targeting of paternal Ube3a-ATS with a high-fidelity CRISPR-Cas13 (hfCas13x.1) system could restore Ube3a … Web1 de fev. de 2024 · Those high-fidelity Cas13 variants or optimization with minimal collateral effects would be better choices for targeted degradation of RNAs in basic research and therapeutic applications. Moreover, the … can giant african snail be eaten

High-fidelity Cas13 variants for targeted RNA degradation

Web16 de ago. de 2024 · The study, published in Nature Biotechnology in the paper, “ High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects, ” demonstrates the feasibility of hfCas13 for efficient on-target RNA degradation with almost no collateral damage in mammalian cells and animals. Concerns have been raised over … WebHigh-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects. Tong H, Huang J, Xiao Q, He B, Dong X, Liu Y, Yang X, Han D, Wang Z ... vector for … Web29 de ago. de 2024 · Off-target editing is also a critical issue in the Cas13 system, although Cas13 is already applied to the knockdown of transcripts, editing of base RNA and live … can giant african land snails eat watermelon